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Helmsley Middletowne Hotel Hotels » Moderate 148 E 48th St, Manhattan New York, NY 10017 Website Read reviews  Map, Add to Itinerary Subway Directions: To this Location or From this Location The Helmsley Middletowne Hotel is located on the East side of Manhattan on 48th Street. The hotel is pure New York and totally Helmsley. Enjoy the kind of hospitality that makes UN diplomats, corporate executives, and people who value the special ambian...